A New Approach for Near-Field Wideband Synthetic Aperture Beamforming

A coarray-based synthetic aperture beamformer using stepped-frequency signal synthesis and post-data acquisition processing is presented for wideband imaging of near-field scenes. The proposed beamformer formulation and implementation finds key applications in through-the-wall microwave imaging and landmine detection problems. While coarray techniques offer significant reduction in array elements for a given angular resolution, stepped-frequency realization of wideband systems simplifies implementation and offers flexibility in beamforming. Proof of concept is provided using real data collected in an anechoic chamber

Design and Implementation of Near-Field, Wideband Synthetic Aperture Beamformers

A coarray-based near-field, wideband synthetic aperture beamformer using stepped-frequency signal synthesis and post-data acquisition processing is presented. While coarray techniques offer significant reduction in the number of array elements for a given angular resolution, the hybrid subarray-stepped frequency realization of wideband systems simplifies implementations and offers flexibility in beamforming. Proof of concept is provided using real data collected in an anechoic chamber for several pulse shapes and array weightings

A Wideband, Synthetic Aperture Beamformer for Through-The-Wall Imaging

A coarray-based aperture synthesis scheme using subarrays and post-data acquisition beamforming is presented for through-the-wall wideband microwave imaging applications. Various effects of the presence of the wall, such as refraction, change in speed, and attenuation, are incorporated into the beamformer design. Simulation results verifying the proposed synthetic aperture technique for a TWI system are presented. The effects of incorrect estimates of the parameters of the wall, such as thickness and dielectric constant, on performance are investigated

Simultaneous operation of two over-the-horizon radars

Abstract—By exploiting the reflective and refractive nature of high-frequency (HF) radiowave propagation through the iono-sphere or the conducting sea surface, over-the-horizon radar (OTHR) systems perform wide-area surveillance at long range well beyond the limit of the horizon of conventional line-of-sight (LOS) radars. Improved characterizations of the targets can be achieved by using multiple OTHRs operating simultaneously as compared to a single OTHR operating alone. In this paper, we consider concurrent operations of two OTHR systems that occupy the same frequency band with different chirp waveforms. The objective is to respond to the advanced wide-area surveillance needs without reducing the wave repetitive frequency. For this purpose, a new cross-radar interference cancellation technique is developed and its effectiveness is verified through both analytical and simulation results. I

Chandra and Spitzer unveil heavily obscured quasars in the SWIRE/Chandra Survey

Using the large multi-wavelength data set in the chandra/SWIRE Survey (0.6 square degrees in the Lockman Hole), we show evidence for the existence of highly obscured (Compton-thick) AGN, estimate a lower limit to their surface density and characterize their multi-wavelength properties. Two independent selection methods based on the X-ray and infrared spectral properties are presented. The two selected samples contain 1) 5 X-ray sources with hard X-ray spectra and column densities > 10^24 cm-2, and 2) 120 infrared sources with red and AGN-dominated infrared spectral energy distributions (SEDs). We estimate a surface density of at least 25 Compton-thick AGN per square degree detected in the infrared in the chandra/SWIRE field of which ~40% show distinct AGN signatures in their optical/near-infrared SEDs, the remainings being dominated by the host-galaxy emission. Only ~33% of all Compton-thick AGN are detected in the X-rays at our depth (F(0.3-8 keV)>10^-15 erg/cm2/s. We report the discovery of two sources in our sample of Compton-thick AGN, SWIRE_J104409.95+585224.8 (z=2.54) and SWIRE_J104406.30+583954.1 (z=2.43), which are the most luminous Compton-thick AGN at high-z currently known. The properties of these two sources are discussed in detail with an analysis of their spectra, SEDs, luminosities and black-hole masses.Comment: ApJ accepted (to appear in May 2006 issue, vol. 642, of ApJ) Figures 2, 3, and 14 have been degraded due to space consideration

SWIRE: The SIRTF Wide‐Area Infrared Extragalactic Survey

The SIRTF Wide-Area Infrared Extragalactic Survey (SWIRE), the largest SIRTF Legacy program, is a wide-area imaging survey to trace the evolution of dusty, star-forming galaxies, evolved stellar populations, and active galactic nuclei (AGNs) as a function of environment, from redshifts to the current z ∼ 3 epoch. SWIRE will survey seven high-latitude fields, totaling 60–65 deg2 in all seven SIRTF bands: Infrared Array Camera (IRAC) 3.6, 4.5, 5.6, and 8 mm and Multiband Imaging Photometer for SIRTF (MIPS) 24, 70, and 160 mm. Extensive modeling suggests that the Legacy Extragalactic Catalog may contain in excess of 2 million IR-selected galaxies, dominated by (1) ∼150,000 luminous infrared galaxies (LIRGs; LFIR 1 1011 L,) detected by MIPS (and significantly more detected by IRAC), ∼7000 of these with ; (2) 1 million IRAC- z 1 2 detected early-type galaxies (∼ with and ∼10,000 with ); and (3) ∼20,000 classical AGNs 5 2 # 10 z 1 1 z 1 2 detected with MIPS, plus significantly more dust-obscured quasi-stellar objects/AGNs among the LIRGs. SWIRE will provide an unprecedented view of the evolution of galaxies, structure, and AGNs. The key scientific goals of SWIRE are (1) to determine the evolution of actively star forming and passively evolving galaxies in order to understand the history of galaxy formation in the context of cosmic structure formation; (2) to determine the evolution of the spatial distribution and clustering of evolved galaxies, starbursts, and AGNs in the key redshift range over which much of cosmic evolution has occurred; and (3) to 0.5 ! z ! 3 determine the evolutionary relationship between “normal galaxies” and AGNs and the contribution of AGN accretion energy versus stellar nucleosynthesis to the cosmic backgrounds. The large area of SWIRE is important to establish statistically significant population samples over enough volume cells that we can resolve the star formation history as a function of epoch and environment, i.e., in the context of structure formation. The large volume is also optimized for finding rare objects. The SWIRE fields are likely to become the next generation of large “cosmic windows” into the extragalactic sky. They have been uniquely selected to minimize Galactic cirrus emission over large scales. The Galaxy Evolution Explorer will observe them as part of its deep 100 deg2 survey, as will Herschel. SWIRE includes ∼9 deg2 of the unique large-area XMM Large Scale Structure hard X-ray imaging survey and is partly covered by the UKIDSS deep J and K survey. An extensive optical/near-IR imaging program is underway from the ground. The SWIRE data are nonproprietary; catalogs and images will be released twice yearly, beginning about 11 months after SIRTF launch. Details of the data products and release schedule are presented

Mapping targets for small nucleolar RNAs in yeast

Background: Recent analyses implicate changes in the expression of the box C/D class of small nucleolar RNAs (snoRNAs) in several human diseases. Methods: Here we report the identification of potential novel RNA targets for box C/D snoRNAs in budding yeast, using the approach of UV crosslinking and sequencing of hybrids (CLASH) with the snoRNP proteins Nop1, Nop56 and Nop58. We also developed a bioinformatics approach to filter snoRNA-target interactions for bona fide methylation guide interactions. Results: We recovered 241,420 hybrids, out of which 190,597 were classed as reproducible, high energy hybrids. As expected, the majority of snoRNA interactions were with the ribosomal RNAs (rRNAs). Following filtering, 117,047 reproducible hybrids included 51 of the 55 reported rRNA methylation sites. The majority of interactions at methylation sites were predicted to guide methylation. However, competing, potentially regulatory, binding was also identified. In marked contrast, following CLASH performed with the RNA helicase Mtr4 only 7% of snoRNA-rRNA interactions recovered were predicted to guide methylation. We propose that Mtr4 functions in dissociating inappropriate snoRNA-target interactions. Numerous snoRNA-snoRNA interactions were recovered, indicating potential cross regulation. The snoRNAs snR4 and snR45 were recently implicated in site-directed rRNA acetylation, and hybrids were identified adjacent to the acetylation sites. We also identified 1,368 reproducible snoRNA-mRNA interactions, representing 448 sites of interaction involving 39 snoRNAs and 382 mRNAs. Depletion of the snoRNAs U3, U14 or snR4 each altered the levels of numerous mRNAs. Targets identified by CLASH were over-represented among these species, but causality has yet to be established. Conclusions: Systematic mapping of snoRNA-target binding provides a catalogue of high-confidence binding sites and indicates numerous potential regulatory interactions

A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

The gene FKBP5 codes for FKBP51, a co-chaperone protein of the Hsp90 complex that increases with age. Through its association with Hsp90, FKBP51 regulates the glucocorticoid receptor (GR). Single nucleotide polymorphisms (SNPs) in the FKBP5 gene associate with increased recurrence of depressive episodes, increased susceptibility to post-traumatic stress disorder, bipolar disorder, attempt of suicide, and major depressive disorder in HIV patients. Variation in one of these SNPs correlates with increased levels of FKBP51. FKBP51 is also increased in HIV patients. Moreover, increases in FKBP51 in the amygdala produce an anxiety phenotype in mice. Therefore, we tested the behavioral consequences of FKBP5 deletion in aged mice. Similar to that of naïve animals treated with classical antidepressants FKBP5−/− mice showed antidepressant behavior without affecting cognition and other basic motor functions. Reduced corticosterone levels following stress accompanied these observed effects on depression. Age-dependent anxiety was also modulated by FKBP5 deletion. Therefore, drug discovery efforts focused on depleting FKBP51 levels may yield novel antidepressant therapies

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts